The small, chromatin-associated HMGA proteins contain three separate DNA binding
domains, so-called AT hooks, which bind preferentially to short AT-rich sequences. These …

The curiosity to understand the mechanisms regulating transcription in pluripotent cells
resulted in identifying a unique transcription factor named Undifferentiated embryonic cell …

Embryonic NANOG (NANOG 1) is considered as an important regulator of pluripotency while
NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG …

Embryonic stem cell (ESC) pluripotency requires bivalent epigenetic modifications of key
developmental genes regulated by various transcription factors and chromatin-modifying …

Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X
chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST silencing, causing …

Maintaining genome integrity requires the accurate and complete replication of
chromosomal DNA. This is of the utmost importance for embryonic stem cells (ESCs), which …

Induced pluripotent stem cells (iPSCs) are usually clonally derived. The selection of fully
reprogrammed cells generally involves picking of individual colonies with morphology …

Pluripotent human embryonic stem cells (ESCs) can be differentiated in vitro into a variety of
cells which hold promise for transplantation therapy. Human embryonal carcinoma cells …

Background Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells.
Recently, selection of fully reprogrammed cells was achieved based on colony morphology …

Embryonic stem cells and embryonal carcinoma cells share two key characteristics:
pluripotency (the ability to differentiate into endoderm, ectoderm, and mesoderm) and self …