Click chemistry: 1, 2, 3‐triazoles as pharmacophores

SG Agalave, SR Maujan… - Chemistry–An Asian …, 2011 - Wiley Online Library
Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

Fluorine-18 labelled building blocks for PET tracer synthesis

D Van Der Born, A Pees, AJ Poot, RVA Orru… - Chemical Society …, 2017 - pubs.rsc.org
Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Amine‐Catalyzed [3+ 2] Huisgen Cycloaddition Strategy for the Efficient Assembly of Highly Substituted 1, 2, 3‐Triazoles

L Wang, S Peng, LJT Danence, Y Gao… - … –A European Journal, 2012 - Wiley Online Library
An enamine‐catalyzed strategy has been utilized to fully promote the Huisgen [3+ 2]
cycloaddition with a broad spectrum of carbonyl compounds and azides, thereby permitting …

Organocatalytic 1, 3-dipolar cycloaddition reactions of ketones and azides with water as a solvent

DKJ Yeung, T Gao, J Huang, S Sun, H Guo, J Wang - Green chemistry, 2013 - pubs.rsc.org
Organocatalytic 1,3-dipolar cycloaddition reactions of ketones and azides with water as a
solvent - Green Chemistry (RSC Publishing) DOI:10.1039/C3GC41126E Royal Society of …

[PDF][PDF] Copper catalyzed cycloaddition reaction of azidomethyl benzene with 2, 2-di (prop-2-yn-1-yl) propane-1, 3-diol: DFT and QTAIM investigation

M Ghiasifar, T Hosseinnejad, A Ahangar - Progress in Chemical and …, 2022 - sid.ir
1, 2, 3-Triazoles are present in the structure of many natural compounds, and due to their
significant biological features, the synthesis of these compounds is of special importance in …

Recent trends in bioorthogonal click-radiolabeling reactions using fluorine-18

M Pretze, D Pietzsch, C Mamat - Molecules, 2013 - mdpi.com
The increasing application of positron emission tomography (PET) in nuclear medicine has
stimulated the extensive development of a multitude of novel and versatile bioorthogonal …

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study

MAA El-Sayed, WM El-Husseiny… - Journal of enzyme …, 2018 - Taylor & Francis
Abstract A new series of 4, 6-disubstituted 2-(4-(dimethylamino) styryl) quinoline 4a, b–9a, b
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …

Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors

MAI Elbastawesy, AA Aly, M Ramadan… - Bioorganic …, 2019 - Elsevier
Two new series of diethyl 2-[2-(substituted-2-oxo-1, 2-dihydroquinolin-4-yl) hydrazono]-
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …

The application of click chemistry in the synthesis of agents with anticancer activity

N Ma, Y Wang, BX Zhao, WC Ye… - Drug design, development …, 2015 - Taylor & Francis
The copper (I)-catalyzed 1, 3-dipolar cycloaddition between alkynes and azides (click
chemistry) to form 1, 2, 3-triazoles is the most popular reaction due to its reliability …

Direct access to triazole-olefins through catalytic cycloaddition of azides to unsaturated aldehydes

W Li, Q Jia, Z Du, J Wang - Chemical Communications, 2013 - pubs.rsc.org
Direct access to triazole-olefins through catalytic cycloaddition of azides to unsaturated
aldehydes - Chemical Communications (RSC Publishing) DOI:10.1039/C3CC45306E Royal …