Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
The bioinorganic chemistry of mammalian metallothioneins
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …
speculations since the discovery of the protein over 60 years ago. This article guides …
HP1 reshapes nucleosome core to promote phase separation of heterochromatin
Heterochromatin affects genome function at many levels. It enables heritable gene
repression, maintains chromosome integrity and provides mechanical rigidity to the …
repression, maintains chromosome integrity and provides mechanical rigidity to the …
Histone lysine methylation dynamics: establishment, regulation, and biological impact
JC Black, C Van Rechem, JR Whetstine - Molecular cell, 2012 - cell.com
Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
N Justin, Y Zhang, C Tarricone, SR Martin… - Nature …, 2016 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) silences gene expression through
trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense …
trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
The functions of metamorphic metallothioneins in zinc and copper metabolism
Recent discoveries in zinc biology provide a new platform for discussing the primary
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …
The SET-domain protein superfamily: protein lysine methyltransferases
SC Dillon, X Zhang, RC Trievel, X Cheng - Genome biology, 2005 - Springer
The SET-domain protein superfamily: protein lysine methyltransferases | Genome Biology Skip
to main content SpringerLink Account Menu Find a journal Publish with us Track your research …
to main content SpringerLink Account Menu Find a journal Publish with us Track your research …
Many paths to methyltransfer: a chronicle of convergence
HL Schubert, RM Blumenthal, X Cheng - Trends in biochemical sciences, 2003 - cell.com
Abstract S-adenosyl-l-methionine (AdoMet) dependent methyltransferases (MTases) are
involved in biosynthesis, signal transduction, protein repair, chromatin regulation and gene …
involved in biosynthesis, signal transduction, protein repair, chromatin regulation and gene …
SRA-and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation
RNA-directed DNA methylation in Arabidopsis thaliana depends on the upstream synthesis
of 24-nucleotide small interfering RNAs (siRNAs) by RNA POLYMERASE IV (Pol IV), and …
of 24-nucleotide small interfering RNAs (siRNAs) by RNA POLYMERASE IV (Pol IV), and …