A model of discovery: the role of imaging established and emerging non-mammalian models in neuroscience
Rodents have been the dominant animal models in neurobiology and neurological disease
research over the past 60 years. The prevalent use of rats and mice in neuroscience …
research over the past 60 years. The prevalent use of rats and mice in neuroscience …
Strategies for the Generation of Gene Modified Avian Models: Advancement in Avian Germline Transmission, Genome Editing, and Applications
Avian models are valuable for studies of development and reproduction and have important
implications for food production. Rapid advances in genome-editing technologies have …
implications for food production. Rapid advances in genome-editing technologies have …
Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing
Conventional avian genome editing is mediated by isolation, culture, and genome editing of
primordial germ cells (PGCs); screening and propagating the genome-edited PGCs; and …
primordial germ cells (PGCs); screening and propagating the genome-edited PGCs; and …
Successful xenotransplantation of testicular cells following fractionated chemotherapy of recipient birds
MH Blank, AJT Kawaoku, BR Rui, ACO Carreira… - Scientific Reports, 2024 - nature.com
An essential step in the success of germ cell transplantation is the preparation of the
recipient's testicular environment to increase the availability of stem cell niches. However …
recipient's testicular environment to increase the availability of stem cell niches. However …
Efficient gene transfer into zebra finch germline-competent stem cells using an adenoviral vector system
Zebra finch is a representative animal model for studying the molecular basis of human
disorders of vocal development and communication. Accordingly, various functional studies …
disorders of vocal development and communication. Accordingly, various functional studies …
The journey of a generation: advances and promises in the study of primordial germ cell migration
The germline provides the genetic and non-genetic information that passes from one
generation to the next. Given this important role in species propagation, egg and sperm …
generation to the next. Given this important role in species propagation, egg and sperm …
Genome editing of avian species: implications for animal use and welfare
Avian species are used as model systems in research and have contributed to ground-
breaking concepts in developmental biology, immunology, genetics, virology, cancer and …
breaking concepts in developmental biology, immunology, genetics, virology, cancer and …
Single-Cell RNA Sequencing Revealed the Heterogeneity of Gonadal Primordial Germ Cells in Zebra Finch (Taeniopygia guttata)
Primordial germ cells (PGCs) are undifferentiated gametes with heterogeneity, an
evolutionarily conserved characteristic across various organisms. Although dynamic …
evolutionarily conserved characteristic across various organisms. Although dynamic …
Fate decisions of chicken primordial germ cells (PGCs): Development, integrity, sex determination, and self-renewal mechanisms
K Ichikawa, H Horiuchi - Genes, 2023 - mdpi.com
Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of
chicken PGCs in terms of their development, integrity, and sex determination have unique …
chicken PGCs in terms of their development, integrity, and sex determination have unique …
Comparative single‐cell transcriptomic analysis reveals differences in signaling pathways in gonadal primordial germ cells between chicken (Gallus gallus) and zebra …
Primordial germ cells (PGCs) have been used in avian genetic resource conservation and
transgenic animal production. Despite their potential applications to numerous avian taxa …
transgenic animal production. Despite their potential applications to numerous avian taxa …