The reaction of 4-(3, 4-dimethoxyphenyl)-5-aminopyrazoles 7A–D with aromatic and
heterocyclic aldehydes in strong acidic media (trifluoroacetic or formic acid) has been …

An efficient method was developed for the synthesis of 1, 3, 4-trisubstituted pyrazolo [3, 4-b]
pyridines, 3H-pyrazolo [3, 4-c] isoquinolines and 3H-pyrazolo [4, 3-f][1, 7] naphthyridines via …

A novel series of pyrazolo [3, 4-c] isoquinoline derivatives was discovered as B-Raf V600E
inhibitors through scaffold hopping based on a literature lead PLX4720. Further SAR …

2006-06-27 Assigned to EXELIXIS, INC. reassignment EXELIXIS, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BUSSENIUS …

Methods of modulating the activity of multidrug transporters are disclosed. The methods of
modulating the activity of multidrug transporters use compounds that Selectively increase or …

The reaction of 3-amino-4-(3, 4-dimethoxyphenyl) maleimide and the methyl esters of 3-
amino-4-(3, 4-dimethoxyphenyl)-5-R-thiophene-2-carboxylic acids with carbonyl …

Publisher Summary This chapter provides information on five membered ring systems with
more than one N atom. Applications of imidazole-and 1, 2, 3-benzotriazole-containing …

Досліджені синтез 5-аміно-4-бензилпіразолів та їх реакції з карбонільними сполуками в
умовах реакції Пікте—Шпенглера. Розроблено простий препаративний метод синтезу …

Взаимодействием 1-R 2-3-R 1-4-(3, 4-диметоксифенил)-5-аминопиразолов и 2-
метоксикарбонил-3-амино-4-(3, 4-диметоксифенил)-5-метилтиофена с 4-гидрокси-3, 5 …

Исследованы реакции 3-амино-4-(3, 4-диметоксифенил) малеимида и метиловых
эфиров 3-амино-4-(3, 4-диметоксифенил)-5-R-тиофен-2-карбоновых кислот с карбо …