Mitogen-and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states

H Sattarifard, A Safaei, E Khazeeva… - … and Cell Biology, 2023 - cdnsciencepub.com
The mitogen-and stress-activated protein kinases (MSK) are epigenetic modifiers that
regulate gene expression in normal and disease cell states. MSK1 and 2 are involved in a …

[HTML][HTML] A novel glycoprotein from earthworm extract PvE-3: Insights of their characteristics for promoting diabetic wound healing and attenuating methylglyoxal …

W Wang, J Ye, Z Guo, Y Ma, Q Yang, W Zhong… - International Journal of …, 2023 - Elsevier
Diabetic chronic wound is a worldwide medical burden related to overdosed methylglyoxal
(MGO) synthesis, which is the major precursor of glycation of proteins and DNA and is …

Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells

Y Gao, B Ma, Y Li, X Wu, S Zhao, H Guo, Y Wang… - Cell Death …, 2023 - nature.com
Many different types of stem cells utilize asymmetric cell division (ACD) to produce two
daughter cells with distinct fates. Haspin-catalyzed phosphorylation of histone H3 at Thr3 …

Leveraging metabolic modeling and machine learning to uncover modulators of quiescence depth

A Eames, S Chandrasekaran - PNAS nexus, 2024 - academic.oup.com
Quiescence, a temporary withdrawal from the cell cycle, plays a key role in tissue
homeostasis and regeneration. Quiescence is increasingly viewed as a continuum between …

Inferring Metabolic Objectives and Tradeoffs in Single Cells During Embryogenesis

DW Lin, L Zhang, J Zhang, S Chandrasekaran - bioRxiv, 2024 - biorxiv.org
While proliferating cells optimize their metabolism to produce biomass, the metabolic
objectives of cells that perform non-proliferative tasks are unclear. The opposing …

Docosahaenoic acid (DHA) exerts its anti-atherogenic effects in endothelial cells via epigenetic and transcriptional mechanisms

S Huang - 2022 - mspace.lib.umanitoba.ca
Atherosclerosis, the main contributor to a range of cardiovascular diseases, can be
regulated by various epigenetic and transcriptional mechanisms, including p38 mitogen …