The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of
dopaminergic neurons within the substantia nigra pars compacta and the reduction in …

Background The effects of insulin-like growth factor-1 (IGF-1) deficiency on cognitive decline
have been consistently reported in animal studies, but the relationship between IGF-1 and …

Introduction Parkinson's disease (PD) is the most common movement disorder, and its
prevalence is increasing rapidly worldwide with an ageing population. The UK Biobank is …

Objective The results of previous studies on sex differences in mortality and comorbidities
among patients with acromegaly are diverse. We assessed sex differences in mortality and …

Objective Cognitive deficits are common in Parkinson's disease (PD) since the early stages
and many patients eventually develop dementia. Yet, occurrence of dementia in PD is …

Background and Objectives A few recent studies have reported an association between
insulin-like growth factor-1 (IGF-1) and neurodegenerative disease, but there was no report …

Parkinson's disease (PD) is the second most frequent neurodegenerative disease
associated with motor dysfunction secondary to the loss of dopaminergic neurons in the …

Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth,
differentiation, repair, and survival of neurons, playing a role in the maintenance of the …

The identification of phenotype-driven network modules in complex, multifluid metabolomics
data poses a considerable challenge for statistical analysis and result interpretation. This is …