Neurobiological basis of stress resilience

EJ Nestler, SJ Russo - Neuron, 2024 - cell.com
A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …

[HTML][HTML] Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis

H Xue, J Chen, W Fan - Journal of Affective Disorders, 2024 - Elsevier
Background Observational studies suggested that immune system disorder is associated
with depression. However, the causal association has not been fully elucidated. Thus, we …

SIR+ models: accounting for interaction-dependent disease susceptibility in the planning of public health interventions

MM Martignoni, A Raulo, O Linkovski, O Kolodny - Scientific Reports, 2024 - nature.com
Avoiding physical contact is regarded as one of the safest and most advisable strategies to
follow to reduce pathogen spread. The flip side of this approach is that a lack of social …

Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior

D Spengler, T Rein - Signal transduction and targeted therapy, 2024 - nature.com
In a study recently published in Nature, Cathomas et al. 1 report that social stress in mice
increases the levels of matrix metalloprotease (MMP) 8 in circulating immune cells, thereby …

Depression: Monocytes on my mind

GP Lazzarino, D Engblom - Immunity, 2024 - Elsevier
Activation of the peripheral immune system contributes to stress-related neuropsychiatric
symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social …

Machine learning algorithms integrate bulk and single-cell RNA data to unveil oxidative stress following intracerebral hemorrhage

C Du, C Wang, Z Liu, W Xin, Q Zhang, A Ali… - International …, 2024 - Elsevier
Background Increased oxidative stress (OS) activity following intracerebral hemorrhage
(ICH) had significantly impacting patient prognosis. Identifying optimal genes associated …

Association between mild depressive states in polycystic ovary syndrome and an unhealthy lifestyle

L Li, Z Kang, P Chen, B Niu, Y Wang… - Frontiers in Public …, 2024 - frontiersin.org
Objective Polycystic Ovary Syndrome (PCOS) is a prevalent and frequently encountered
gynecological disorder. Its high variability and the complexities associated with its …

[HTML][HTML] Microglial MyD88-dependent pathways are regulated in a sex specific manner in the context of HMGB1-induced anxiety

A Rawls, D Nyugen, J Dziabis, D Anbarci, M Clark… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Chronic stress is a major risk factor for development and recurrence of anxiety disorders.
Chronic stress has been shown to impact the immune system, causing microglial activation …

Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity

HSH Oh, Y Le Guen, N Rappoport, DY Urey… - bioRxiv, 2024 - biorxiv.org
Organ-derived plasma protein signatures derived from aptamer protein arrays track organ-
specific aging, disease, and mortality in humans, but the robustness and clinical utility of …

MMP8 and stress susceptibility

D Yates - Nature Reviews Neuroscience, 2024 - nature.com
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