Neurobiological basis of stress resilience
EJ Nestler, SJ Russo - Neuron, 2024 - cell.com
A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …
function, a process referred to as resilience. Such stress resilience has been modeled in …
[HTML][HTML] Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis
H Xue, J Chen, W Fan - Journal of Affective Disorders, 2024 - Elsevier
Background Observational studies suggested that immune system disorder is associated
with depression. However, the causal association has not been fully elucidated. Thus, we …
with depression. However, the causal association has not been fully elucidated. Thus, we …
SIR+ models: accounting for interaction-dependent disease susceptibility in the planning of public health interventions
Avoiding physical contact is regarded as one of the safest and most advisable strategies to
follow to reduce pathogen spread. The flip side of this approach is that a lack of social …
follow to reduce pathogen spread. The flip side of this approach is that a lack of social …
Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior
D Spengler, T Rein - Signal transduction and targeted therapy, 2024 - nature.com
In a study recently published in Nature, Cathomas et al. 1 report that social stress in mice
increases the levels of matrix metalloprotease (MMP) 8 in circulating immune cells, thereby …
increases the levels of matrix metalloprotease (MMP) 8 in circulating immune cells, thereby …
Depression: Monocytes on my mind
GP Lazzarino, D Engblom - Immunity, 2024 - Elsevier
Activation of the peripheral immune system contributes to stress-related neuropsychiatric
symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social …
symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social …
Machine learning algorithms integrate bulk and single-cell RNA data to unveil oxidative stress following intracerebral hemorrhage
C Du, C Wang, Z Liu, W Xin, Q Zhang, A Ali… - International …, 2024 - Elsevier
Background Increased oxidative stress (OS) activity following intracerebral hemorrhage
(ICH) had significantly impacting patient prognosis. Identifying optimal genes associated …
(ICH) had significantly impacting patient prognosis. Identifying optimal genes associated …
Association between mild depressive states in polycystic ovary syndrome and an unhealthy lifestyle
L Li, Z Kang, P Chen, B Niu, Y Wang… - Frontiers in Public …, 2024 - frontiersin.org
Objective Polycystic Ovary Syndrome (PCOS) is a prevalent and frequently encountered
gynecological disorder. Its high variability and the complexities associated with its …
gynecological disorder. Its high variability and the complexities associated with its …
[HTML][HTML] Microglial MyD88-dependent pathways are regulated in a sex specific manner in the context of HMGB1-induced anxiety
Chronic stress is a major risk factor for development and recurrence of anxiety disorders.
Chronic stress has been shown to impact the immune system, causing microglial activation …
Chronic stress has been shown to impact the immune system, causing microglial activation …
Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity
Organ-derived plasma protein signatures derived from aptamer protein arrays track organ-
specific aging, disease, and mortality in humans, but the robustness and clinical utility of …
specific aging, disease, and mortality in humans, but the robustness and clinical utility of …
MMP8 and stress susceptibility
D Yates - Nature Reviews Neuroscience, 2024 - nature.com
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