The ETV6 (also known as TEL) gene encodes a transcriptional repressor that plays a critical
role in hematopoiesis and in embryonic development. While somatic ETV6 translocations …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

Some familial platelet disorders are associated with predisposition to leukemia,
myelodysplastic syndrome (MDS) or dyserythropoietic anemia,. We identified a family with …

Patients with thrombocytopenia 5 have an autosomal dominant disorder of decreased
platelet number with tendency to bleed, usually presenting in childhood, and have been …

Advances in molecular genetic sequencing techniques have contributed to the elucidation of
previously unknown germline mutations responsible for inherited thrombocytopenia (IT) …

Zebrafish is an established model for the study of vertebrate development, and is especially
amenable for investigating hematopoiesis, where there is strong conservation of key …

At least thirteen ETS-domain transcription factors are expressed during embryonic
hematopoietic or vascular development and potentially function in the formation and …

Abstract ETV6 (TEL1) and ETV7 (TEL2) are closely-related members of the ETS family of
transcriptional regulators. Both ETV6 and ETV7 have been demonstrated to play key roles in …

Background Tumor metastasis is one of the main causes of the high mortality of
hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong …

Simple Summary Despite remarkable progress in the treatment of acute lymphoblastic
leukemia (ALL) in recent years, it remains a significant contributor to pediatric cancer-related …