New biotech applications from evolved D-amino acid oxidases
L Pollegioni, G Molla - Trends in biotechnology, 2011 - cell.com
d-Amino acid oxidase (DAAO) is a well-known flavoenzyme that catalyzes the oxygen-
dependent oxidative deamination of amino acid D-isomers with absolute stereospecificity …
dependent oxidative deamination of amino acid D-isomers with absolute stereospecificity …
Properties and applications of microbial D-amino acid oxidases: current state and perspectives
D-Amino acid oxidase (DAAO) is a biotechnologically relevant enzyme that is used in a
variety of applications. DAAO is a flavine adenine dinucleotide-containing flavoenzyme that …
variety of applications. DAAO is a flavine adenine dinucleotide-containing flavoenzyme that …
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer's disease in the human hippocampus
Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such
as Alzheimer's disease (AD), strongly affect quality of life. Using an integrated omics …
as Alzheimer's disease (AD), strongly affect quality of life. Using an integrated omics …
Serum d-serine levels are altered in early phases of Alzheimer's disease: towards a precocious biomarker
L Piubelli, L Pollegioni, V Rabattoni, M Mauri… - Translational …, 2021 - nature.com
Abstract d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which
appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR …
appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR …
Hydrophilicity‐based engineering of the active pocket of D‐amino acid oxidase leading to highly improved specificity toward D‐glufosinate
K Yang, B Huang, C Amanze, Z Yan, G Qiu… - Angewandte …, 2022 - Wiley Online Library
Due to its stringent stereospecificity, D‐amino acid oxidase (DAAO) has made it very easy to
synthesize L‐amino acids. However, the low activity of the wild‐type enzyme toward …
synthesize L‐amino acids. However, the low activity of the wild‐type enzyme toward …
D-Amino acid oxidase: structure, catalytic mechanism, and practical application
VI Tishkov, SV Khoronenkova - Biochemistry (Moscow), 2005 - Springer
D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme that plays an important role in
microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous …
microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous …
[HTML][HTML] Characterization of human D-amino acid oxidase
d-Amino acid oxidase (DAAO) has been proposed to be involved in the oxidation of d-
serine, an allosteric activator of the NMDA-type glutamate receptor in the brain, and to be …
serine, an allosteric activator of the NMDA-type glutamate receptor in the brain, and to be …
Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels
K Yamada, T Ohnishi, K Hashimoto, H Ohba… - Biological …, 2005 - Elsevier
BACKGROUND: We previously reported a reduction in serum levels of d-serine, an
endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, in schizophrenia …
endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, in schizophrenia …
Age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging
The endogenous NMDA receptor (NMDAR) agonist d-aspartate occurs transiently in the
mammalian brain because it is abundant during embryonic and perinatal phases before …
mammalian brain because it is abundant during embryonic and perinatal phases before …
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy
Over the years, accumulating evidence has indicated that D-serine represents the
endogenous ligand for the glycinemodulatory binding site on the NR1 subunit of N-methyl-D …
endogenous ligand for the glycinemodulatory binding site on the NR1 subunit of N-methyl-D …