The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …

Sleep deprivation disrupts the lives of millions of people every day and has a profound
impact on the molecular biology of the brain. These effects begin as changes within a …

Depression is a serious and potentially life-threatening mental disorder with unknown
etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and …

Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …

miR-124, a brain-specific microRNA, was originally considered as a key regulator in
neuronal differentiation and the development of the nervous system. Here we showed that …

Evolved under the selective pressures of a 24-h world, circadian timekeeping mechanisms
are present in virtually all living organisms to coordinate daily rhythms in physiology and …

The human genome project has revolutionized our understanding of the underlying
mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral …

Hypocretin (Hcrt), also known as orexin, neuropeptide signaling stabilizes sleep and
wakefulness in all vertebrates. A lack of Hcrt causes the sleep disorder narcolepsy, and …