Pluripotent stem cells are endless sources for in vitro engineering human tissues for
regenerative medicine. Extensive studies have demonstrated that transcription factors are …

RNA sequencing (RNA-seq) enables the accurate measurement of multiple transcriptomic
phenotypes for modeling the impacts of disease variants. Advances in technologies …

The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged
mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective …

Parkinson's disease (PD) is a complex neurodegenerative disorder without a cure. The
onset of PD symptoms corresponds to 50% loss of midbrain dopaminergic (mDA) neurons …

Mild cognitive impairment (MCI) is a common trait of Parkinson's disease (PD), often
associated with early motor deficits, eventually evolving to PD with dementia in later disease …

Dopaminergic neurons participate in fundamental physiological processes and are the cell
type primarily affected in Parkinson's disease. Their analysis is challenging due to the …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, with an
unknown etiology and no specific treatment. Emerging single-cell and single-nucleus RNA …

Data mining involves the computational analysis of a plethora of publicly available datasets
to generate new hypotheses that can be further validated by experiments for the improved …

Autism is a developmental disability. Research demonstrated that children with autism
benefit from early diagnosis and early intervention. Genetic factors are considered major …

The investigation of neurodegenerative diseases advanced significantly with the advent of
cell-reprogramming technology, leading to the creation of new models of human illness …