Tumor necrosis factor (TNF) is a proinflammatory cytokine that is produced and secreted by
cytotoxic lymphocytes upon tumor target recognition. Depending on the context, TNF can …

Ubiquitination is a fundamental post-translational modification that regulates almost all
aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases …

Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation,
diminishing adaptive CD8+ T cell antitumor activity. Although innate natural killer (NK) cells …

Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like
(MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell …

The Purdue Make It system is a unique automated platform capable of small-scale in situ
synthesis, screening small-molecule reactions, and performing direct label-free bioassays …

The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and
innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP …

Ubiquitination is an essential post-translational modification that regulates most cellular
processes. The assembly of ubiquitin into polymeric chains by E3 ubiquitin ligases underlies …

The success of cancer immunotherapy is limited to a subset of patients, highlighting the
need to identify the processes by which tumors evade immunity. Using CRISPR/Cas9 …

The linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin ligase composed of the
Heme-oxidized IRP2 ubiquitin ligase-1L (HOIL-1L), HOIL-1L-interacting protein (HOIP), and …

Nuclear factor-κB (NF-κB) is a crucial transcription factor family involved in the regulation of
immune and inflammatory responses and cell survival. The linear ubiquitin chain assembly …