The future of rodent models in depression research

A Gururajan, A Reif, JF Cryan, DA Slattery - Nature Reviews …, 2019 - nature.com
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

A comprehensive approach to modeling maternal immune activation in rodents

MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …

Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model

BC Nephew, A Nemeth, N Hudda, G Beamer… - Environmental …, 2020 - Elsevier
Recent studies indicate that exposure to airborne particulate matter (PM) is associated with
cognitive delay, depression, anxiety, autism, and neurodegenerative diseases; however, the …

Proximity to humans affects local social structure in a giraffe metapopulation

ML Bond, B König, DE Lee, A Ozgul… - Journal of Animal …, 2021 - Wiley Online Library
Experimental laboratory evidence suggests that animals with disrupted social systems
express weakened relationship strengths and have more exclusive social associations, and …

The underestimated sex: A review on female animal models of depression

S Lima, N Sousa, P Patricio, L Pinto - Neuroscience & Biobehavioral …, 2022 - Elsevier
Major depression (MD) is the most common psychiatric disorder, predicted to affect around
264 million people worldwide. Although the etiology of depression remains elusive, the …

Psychosocial stress and immunity—what can we learn from pig studies?

U Gimsa, M Tuchscherer, E Kanitz - Frontiers in Behavioral …, 2018 - frontiersin.org
Psychosocial stress may impair immune functions and provoke the development of
pathologies. The underlying communication between the brain and the immune system is …

[HTML][HTML] The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations

A Koert, A Ploeger, CLH Bockting, MV Schmidt… - Neurobiology of …, 2021 - Elsevier
Background Social stress is an important environmental risk factor for the development of
psychiatric disorders, including depression and anxiety disorders. Social stress paradigms …

Social instability in female rodents as a model of stress related disorders: a systematic review

O Goni-Balentziaga, J Perez-Tejada… - Physiology & …, 2018 - Elsevier
The risk of developing stress related disorders such as depression is two times higher in
women than in men, and social stress is considered the principal etiology for this disorder …

Repeated three-hour maternal deprivation as a model of early-life stress alters maternal behavior, olfactory learning and neural development

D Czarnabay, J Dalmago, AS Martins, A Queiroz… - … of Learning and …, 2019 - Elsevier
Early life stress such as physical abuse, trauma or neglect during a critical period of
development can elicit negative long-lasting effects on health. Neonatal maternal …

The behavioral and molecular evaluation of effects of social instability stress as a model of stress-related disorders in adult female rats

MM Nowacka-Chmielewska, D Kasprowska-Liśkiewicz… - Stress, 2017 - Taylor & Francis
The study aimed to test the hypotheses that chronic social instability stress (CSIS) alters
behavioral and physiological parameters and expression of selected genes important for …