In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …

Humans are exposed to nanoscopical nanobiovectors (eg coronavirus SARS-CoV-2) as
well as abiotic metal/carbon-based nanomaterials that enter cells serendipitously or …

During clathrin-mediated endocytosis, dozens of proteins assemble into an interconnected
network at the plasma membrane. As initiators of endocytosis, Eps15 and Fcho1/2 …

Autophagy eliminates cytoplasmic content selected by autophagy receptors, which link
cargo to the membrane-bound autophagosomal ubiquitin-like protein Atg8/LC3. Here, we …

The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the
host cell surface and subsequently enters host cells through receptor-mediated endocytosis …

Clathrin-mediated endocytosis (CME) is the primary mechanism eukaryotic cells use to
internalize material. New imaging tools are revealing the nanoscale structural dynamics of …

Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also
participates to a diverse range of cellular functions. Key to this is clathrin's ability to …

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) canonically utilizes
clathrin-mediated endocytosis (CME) and several other endocytic mechanisms to invade …

The transport of proteins between the different cellular compartments and the cell surface is
governed by the secretory pathway. Alternatively, unconventional secretion pathways have …

Endocytosis, the process by which cells internalize plasma membrane and associated
cargo, is regulated extensively by posttranslational modifications. Previous studies …