Achieving clinical success with BET inhibitors as anti-cancer agents
T Shorstova, WD Foulkes, M Witcher - British journal of cancer, 2021 - nature.com
The transcriptional upregulation of oncogenes is a driving force behind the progression of
many tumours. However, until a decade ago, the concept of 'switching off'these oncogenic …
many tumours. However, until a decade ago, the concept of 'switching off'these oncogenic …
[HTML][HTML] The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?
A Marx, JKC Chan, L Chalabreysse, S Dacic… - Journal of Thoracic …, 2022 - Elsevier
This overview of the fifth edition of the WHO classification of thymic epithelial tumors
(including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]) …
(including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]) …
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
K Krupina, A Goginashvili, DW Cleveland - Nature Reviews Genetics, 2024 - nature.com
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …
An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients
Background NUT midline carcinoma, renamed NUT carcinoma (NC), is an aggressive
squamous cancer defined by rearrangement of the NUTM1 gene. Although a subset of …
squamous cancer defined by rearrangement of the NUTM1 gene. Although a subset of …
[HTML][HTML] Tracing oncogene rearrangements in the mutational history of lung adenocarcinoma
Mutational processes giving rise to lung adenocarcinomas (LADCs) in non-smokers remain
elusive. We analyzed 138 LADC whole genomes, including 83 cases with minimal …
elusive. We analyzed 138 LADC whole genomes, including 83 cases with minimal …
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment
CA French - Pathology international, 2018 - Wiley Online Library
NUT carcinoma (NC) is a rare, aggressive subtype of squamous cell carcinoma defined by
rearrangement of the NUTM1 (aka NUT) gene. NC is driven by NUT‐fusion oncoproteins …
rearrangement of the NUTM1 (aka NUT) gene. NC is driven by NUT‐fusion oncoproteins …
Patterns and mechanisms of structural variations in human cancer
K Yi, YS Ju - Experimental & molecular medicine, 2018 - nature.com
Next-generation sequencing technology has enabled the comprehensive detection of
genomic alterations in human somatic cells, including point mutations, chromosomal …
genomic alterations in human somatic cells, including point mutations, chromosomal …
Supercharging BRD4 with NUT in carcinoma
KP Eagen, CA French - Oncogene, 2021 - nature.com
NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy.
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …
BET proteins: Biological functions and therapeutic interventions
J Guo, Q Zheng, Y Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …
BET proteins as attractive targets for cancer therapeutics
J Sarnik, T Popławski, P Tokarz - International journal of molecular …, 2021 - mdpi.com
Transcriptional dysregulation is a hallmark of cancer and can be an essential driver of
cancer initiation and progression. Loss of transcriptional control can cause cancer cells to …
cancer initiation and progression. Loss of transcriptional control can cause cancer cells to …