Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13
amplicon, one of the most frequently amplified chromosomal regions in human cancer, but …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

Abstract Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In
macrophages, transient stimulation of P2X7R activates several transport mechanisms and …

Abstract Background MicroRNA-381 (miR-381) has been reported to play suppressive or
promoting roles in different malignancies. However, the expression level, biological function …

TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …