The development of genetic sex determination and cytologically distinct sex chromosomes
leads to the potential problem of gene dosage imbalances between autosomes and sex …

Differentiated sex chromosomes in mammals and other vertebrates evolved independently
but in strikingly similar ways. Vertebrates with differentiated sex chromosomes share the …

Once protein-coding, the X-inactivation center (Xic) is now dominated by large noncoding
RNAs (ncRNA). X chromosome inactivation (XCI) equalizes gene expression between …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …

In therian mammals (placentals and marsupials), sex is determined by an XX female: XY
male system, in which a gene (SRY) on the Y affects male determination. There is no …

Combining genome assembly with population and functional genomics can provide
valuable insights to development and evolution, as well as tools for species management …

Background We present the genome sequence of the tammar wallaby, Macropus eugenii,
which is a member of the kangaroo family and the first representative of the iconic hopping …

Background An increasing number of long noncoding RNAs (lncRNAs) have been identified
recently. Different from all the others that function in cis to regulate local gene expression …

X-chromosome inactivation, which occurs in female eutherian mammals is controlled by a
complex X-linked locus termed the X-inactivation center (XIC). Previously it was proposed …

Early in development, placental and marsupial mammals harbouring at least two X
chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of …