Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …

Over the last 8 years, the National Cancer Institute (NCI) has launched a major effort to
integrate molecular and clinical cancer-related information within a unified biomedical …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …

Neuroblastoma stands out among pediatric solid tumors because of its relative frequency,
intriguing natural history, prognostic biologic features, and therapeutic challenges. It is the …

Despite improvements in cancer therapies in the past 50 years, neuroblastoma remains a
devastating clinical problem and a leading cause of childhood cancer deaths. Advances in …

Mammalian target of rapamycin (mTOR) has been shown to play an important function in
cell proliferation, metabolism and tumorigenesis, and proteins that regulate signaling …

C-KIT (CD117), a tyrosine kinase receptor, is involved in the growth and development of
normal tissues and some types of neoplasms. In the present study we analysed the …

Background Neuroblastoma is a devastating disease accounting for 15% of all childhood
cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine …

Pediatric cancers represent a wide variety of different tumors, though they have unique
features that distinguish them from adult cancers. Receptor tyrosine kinases KIT and TrkA …