Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Melanogenesis is the process for the production of melanin, which is the primary cause of
human skin pigmentation. Skin‑whitening agents are commercially available for those who …

Eukaryotic cells create internal order by using protein motors to transport molecules and
organelles along cytoskeletal tracks. Recent genomic and functional studies suggest that …

Life implies movement. Most forms of movement in the living world are powered by tiny
protein machines known as molecular motors. Among the best known are motors that use …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

The Ras superfamily is a fascinating example of functional diversification in the context of a
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …

Microtubules provide long tracks along which a broad range of organelles and vesicles are
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …

Cytotoxic T cells and natural killer cells are crucial for immune surveillance against virus-
infected cells and tumour cells. Molecular studies of individuals with inherited defects that …