Recent advances in microfluidic technology for bioanalysis and diagnostics

SF Berlanda, M Breitfeld, CL Dietsche… - Analytical …, 2020 - ACS Publications
Microfluidics has become a mature technology, providing an excellent toolbox for the
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …

Recent advances in microfluidics for drug screening

J Sun, AR Warden, X Ding - Biomicrofluidics, 2019 - pubs.aip.org
With ever increasing drug resistance and emergence of new diseases, demand for new drug
development is at an unprecedented urgency. This fact has led to extensive recent efforts to …

Artificial intelligence-accelerated high-throughput screening of antibiotic combinations on a microfluidic combinatorial droplet system

D Yang, Z Yu, M Zheng, W Yang, Z Liu, J Zhou… - Lab on a Chip, 2023 - pubs.rsc.org
Microfluidic platforms have been employed as an effective tool for drug screening and
exhibit the advantages of lower reagent consumption, higher throughput and a higher …

An antibiotic concentration gradient microfluidic device integrating surface-enhanced Raman spectroscopy for multiplex antimicrobial susceptibility testing

SJ Lin, PH Chao, HW Cheng, JK Wang, YL Wang… - Lab on a Chip, 2022 - pubs.rsc.org
Antimicrobial susceptibility testing (AST) is a key measure in clinical microbiology
laboratories to enable appropriate antimicrobial administration. During an AST, the …

Acoustofluidic generation of droplets with tunable chemical concentrations

J Park, G Destgeer, M Afzal, HJ Sung - Lab on a Chip, 2020 - pubs.rsc.org
The dynamic control of the chemical concentration within droplets is required in numerous
droplet microfluidic applications. Here, we propose an acoustofluidic method for the …

Hand-powered vacuum-driven microfluidic gradient generator for high-throughput antimicrobial susceptibility testing

W Zeng, P Chen, S Li, Q Sha, P Li, X Zeng… - Biosensors and …, 2022 - Elsevier
The growth of bacterial resistance to antimicrobials is a serious problem attracting much
attention nowadays. To prevent the misuse and abuse of antimicrobials, it is important to …

A microfluidic microwell device operated by the automated microfluidic control system for surface-enhanced Raman scattering-based antimicrobial susceptibility …

CC Liao, YZ Chen, SJ Lin, HW Cheng, JK Wang… - Biosensors and …, 2021 - Elsevier
Bloodstream infection (BSI) is a serious public health issue worldwide. Timely and effective
antibiotics for controlling infection are crucial towards patient outcomes. However, the …

[HTML][HTML] The exposure levels and health risk assessment of antibiotics in urine and its association with platelet mitochondrial DNA methylation in adults from Tianjin …

J Zhang, Z Liu, S Song, J Fang, L Wang, L Zhao… - Ecotoxicology and …, 2022 - Elsevier
There has been extensive research on antibiotics exposure in adults by biomonitoring, but
the biological mechanisms and potential risks to human health remain limited. In this study …

Emerging single-cell microfluidic technology for microbiology

Y Song, J Yin, W Huang, B Li, H Yin - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Cell-to-cell differences exist ubiquitously in microbial communities. This individual
heterogeneity, often manifested in cell phenotypic function (eg, antibiotic resistance), can be …

Bacteria encapsulation and rapid antibiotic susceptibility test using a microfluidic microwell device integrating surface-enhanced Raman scattering

HK Huang, HW Cheng, CC Liao, SJ Lin, YZ Chen… - Lab on a Chip, 2020 - pubs.rsc.org
The antibiotic susceptibility test (AST) is a general laboratory procedure for bacterial
identification and characterization and can be utilized to determine effective antimicrobials …