The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …
[HTML][HTML] MicroRNA delivery through nanoparticles
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …
[HTML][HTML] Recent advances in miRNA delivery systems
I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …
are produced in a tissue and time-specific manner to orchestrate gene expression post …
[HTML][HTML] A comprehensive review of cancer MicroRNA therapeutic delivery strategies
A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating
physiological processes and cancer pathogenesis have been a revolutionary discovery over …
physiological processes and cancer pathogenesis have been a revolutionary discovery over …
MicroRNA replacement therapy in cancer
H Mollaei, R Safaralizadeh… - Journal of cellular …, 2019 - Wiley Online Library
Despite the recent progress in cancer management approaches, the mortality rate of cancer
is still growing and there are lots of challenges in the clinics in terms of novel therapeutics …
is still growing and there are lots of challenges in the clinics in terms of novel therapeutics …
[HTML][HTML] From molecular mechanisms to therapeutics: understanding MicroRNA-21 in cancer
J Rhim, W Baek, Y Seo, JH Kim - Cells, 2022 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in regulating
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …
microRNA‐based diagnostic and therapeutic applications in cancer medicine
LF Sempere, AS Azmi, A Moore - Wiley Interdisciplinary …, 2021 - Wiley Online Library
It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …
[HTML][HTML] Delivery of anti-miRNA for triple-negative breast cancer therapy using RNA nanoparticles targeting stem cell marker CD133
Triple-negative breast cancer (TNBC) is an aggressive disease with a short median time
from relapse to death. The increased aggressiveness, drug resistance, disease relapse, and …
from relapse to death. The increased aggressiveness, drug resistance, disease relapse, and …
Dendrimer nanoparticles for colorectal cancer applications
MR Carvalho, RL Reis, JM Oliveira - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Cancer nanotechnology is a prolific field of research, where nanotools are employed to
diagnose and treat cancer with unprecedented precision. Targeted drug delivery is …
diagnose and treat cancer with unprecedented precision. Targeted drug delivery is …