Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

The liver controls the systemic exposure of amino acids entering via the gastro-intestinal
tract. For most amino acids except branched chain amino acids, hepatic uptake is very …

Neurons are metabolically handicapped in the sense that they are not able to perform de
novo synthesis of neurotransmitter glutamate and γ‐aminobutyric acid (GABA) from glucose …

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

The small intestine mediates the absorption of amino acids after ingestion of protein and
sustains the supply of amino acids to all tissues. The small intestine is an important …

The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family
resemble the classically-described System A and System N transport activities in terms of …

Previous work has identified two families of proteins that transport classical
neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

Amino acid availability regulates cellular physiology by modulating gene expression and
signal transduction pathways. However, although the signalling intermediates between …

Transporters of the SLC38 family are found in all cell types of the body. They mediate Na+-
dependent net uptake and efflux of small neutral amino acids. As a result they are …