Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts …

B cells have a critical role in the initiation and acceleration of autoimmune diseases,
especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation
and proliferation of synovial tissues. Diosmetin is a bioflavonoid possessing an anti …

Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene
expression in circulating immune cells and synovial tissues. Accumulating evidence has …

Angiogenesis is the formation of new capillaries from preexisting vasculature. The
perpetuation of angiogenesis plays a critical role in the pathogenesis of various disease …

Rheumatoid arthritis (RA) is a systemic-autoimmune-mediated disease characterized by
synovial hyperplasia and progressive destruction of joint. Currently available biological …

Abstract Interleukin (IL)-17 predominately produced by the Th17 cells, plays a crucial role in
the fibroblast-like synoviocytes (FLS) mediated disease process of rheumatoid arthritis (RA) …

The CCN family of matricellular proteins (CYR61/CCN1, CTGF/CCN2, NOV/CCN3 and
WISP1-2-3/CCN4-5-6) are essential players in the key pathophysiological processes of …

Autoimmune diseases occur when the immune system loses tolerance to self-antigens,
inducing inflammation and tissue damage. The pathogenesis of autoimmune diseases has …

The acronym for the CCN family was recently revised to represent “cellular communication
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …