There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …

Fibrosis is a characteristic feature in the pathogenesis of a wide spectrum of diseases.
Recently, it was suggested that IL-13-dependent fibrosis develops through a TGF-β1 and …

The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

Schistosoma mansoni infection may occur either as an acute infection in individuals who
have recently visited an endemic area, with no previous contact with the parasite, or as a …

Transforming‐growth factor‐β (TGF‐β) is a pleiotrophic growth factor that is synthesized by
many cells in the body. This growth factor is chemotactic for fibroblasts, stimulates fibroblast …

Schistosoma mansoni infection is highly endemic in parts of Uganda, and periportal fibrosis
is common in communities along the shore of Lake Albert. In this study, we have identified …

Schistosomiasis is the second most debilitating neglected tropical disease globally after
malaria, with no available therapy to control disease-driven immunopathology. Although …

Despite increasing knowledge about molecular pathways in pathogenesis of chronic liver
disease, selective therapeutic options are scarce, especially in advanced diseases …

Background & Aims: Stressful life events are supposed to be involved in various diseases
such as inflammatory bowel diseases and irritable bowel syndrome. Impairment of the …