In the past few years, cancer immunotherapy has emerged as a safe and effective
alternative for treatment of cancers that do not respond to classical treatments, including …

The granzymes are cell death–inducing enzymes, stored in the cytotoxic granules of
cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis …

The photothermal response of plasmonic nanomaterials can be exploited for a number of
biomedical applications in diagnostics (biosensing and optoacoustic imaging) and therapy …

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are indispensable factors in the
body's ongoing defence against viral infection and tumor development. CTL/NK cells …

Cytotoxic T lymphocyte and natural killer cell-initiated cell death is one of the primary
mechanisms used by higher organisms to eliminate viruses and transformed cells. In this …

The caspase family of cysteine proteases becomes activated in response to diverse cellular
insults and coordinates apoptosis through proteolysis of hundreds of cellular substrates …

Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge
economic impact on poultry industry. The continuous emergence of new IBV genotypes and …

Granzyme A (GzmA) is considered a major proapoptotic protease. We have discovered that
GzmA-induced cell death involves rapid membrane damage that depends on the synergy …

Granzyme A (GzmA) is the most abundant serine protease in killer cell cytotoxic granules.
GzmA activates a novel programed cell death pathway that begins in the mitochondrion …

Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate
target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …