Multiple Myeloma is a typical example of a neoplasm that shows significant differences in
incidence, age of onset, type, and frequency of genetic alterations between patients of …

The management of patients with cancer and Li-Fraumeni or heritable TP53-related cancer
syndromes is complex because of their increased risk of developing second malignant …

Cancers harbor many somatic mutations and germline variants, we hypothesized that the
combined effect of germline variants that alter the structure, expression, or function of protein …

Objective Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related
cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified …

Genes carrying high‐penetrance germline mutations may also be associated with cancer
susceptibility through common low‐penetrance genetic variants. To increase the knowledge …

Background Therapy resistance in cancer is often driven by a subpopulation of cells that are
temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose …

Somatic mutations drive cancer development and are relevant to patient responses to
treatment. Emerging evidence shows that variations in the somatic genome can be …

Base editing is an emerging genome editing technology with the advantages of precise
base corrections, no double-strand DNA breaks, and no need for templates, which provides …

Genome-wide association studies (GWAS) have found hundreds of single-nucleotide
polymorphisms (SNP) associated with increased risk of cancer. However, the amount of …

Simple Summary In cancer, regulatory regions of the genome are hijacked by the tumor cells
for the activation of oncogenes that lead to cancer initiation and progression. One of the …