Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases

S Fathi-Karkan, NA Ramsheh, H Arkaban… - International Journal of …, 2024 - Elsevier
This review article provides a comprehensive overview of the advancements in using
nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance …

Biomedical and nutritional applications of lactoferrin

C Coccolini, E Berselli, C Blanco-Llamero… - International Journal of …, 2023 - Springer
Lactoferrin (Lf) is a glycoprotein belonging to the transferrin family, which can be found in
mammalian milk. It was first isolated from bovine milk in the 1930s, and later in the 1960s, it …

Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in …

S Fathy Elhabal, MA El-Nabarawi, N Abdelaal… - Drug Delivery, 2023 - Taylor & Francis
Canagliflozin (CFZ) is a sodium-glucose cotransporter-2 inhibitor (SGLT2) that lowers
albuminuria in type-2 diabetic patients, cardiovascular, kidney, and liver disease. CFZ is …

Intranasal bilosomes in thermosensitive hydrogel: advancing desvenlafaxine succinate delivery for depression management

TM El-Nawawy, YA Adel, M Teaima… - Pharmaceutical …, 2024 - Taylor & Francis
Depression, the second biggest cause of disability worldwide, is widespread. Many
antidepressant medications, including Desvenlafaxine Succinate (DVS), function by …

[HTML][HTML] Enhanced antibacterial activity of clindamycin using molecularly imprinted polymer nanoparticles loaded with polyurethane nanofibrous scaffolds for the …

SF Elhabal, R Abdelmonem, RM El Nashar… - Pharmaceutics, 2024 - mdpi.com
Acne vulgaris, a prevalent skin condition, arises from an imbalance in skin flora, fostering
bacterial overgrowth. Addressing this issue, clindamycin molecularly imprinted polymeric …

[HTML][HTML] Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals

ME Abd El-Hack, SA Abdelnour, M Kamal… - Biomedicine & …, 2023 - Elsevier
Lactoferrin (LF) is a protein found in several bodily fluids, such as milk. This protein has a
diverse range of functions and is evolutionarily conserved. Lactoferrin is a multifunction …

Sertaconazole-PLGA nanoparticles for management of ocular keratitis

NE Eleraky, MA Attia, MA Safwat - Journal of Drug Delivery Science and …, 2024 - Elsevier
Ocular fungal infections can pose severe health conditions that may develop into vision
impairment and blindness. Sertaconazole (STZ) is a widely used antifungal; however, its low …

[HTML][HTML] Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: in vitro and in vivo studies

M Yasser, EE El Naggar, N Elfar, MH Teaima… - International Journal of …, 2024 - Elsevier
The study aims to improve the ocular delivery of Nebivolol HCL (NBV) belonging to the
Biopharmaceutics classification system (BCSII) by using spanlastic nanovesicles (SNVs) for …

Mucoadhesive Hybrid System of Silk Fibroin Nanoparticles and Thermosensitive In Situ Hydrogel for Amphotericin B Delivery: A Potential Option for Fungal Keratitis …

P Chomchalao, N Saelim, S Lamlertthon, P Sisopa… - Polymers, 2024 - mdpi.com
The purpose of this work was to investigate the feasibility of a novel ophthalmic formulation
of amphotericin B-encapsulated silk fibroin nanoparticles incorporated in situ hydrogel (AmB …

Review of nanoformulations for treating ocular fungal infections

AL Onugwu, SC Emencheta, RN Sabastine… - Journal of Drug Delivery …, 2024 - Elsevier
Ocular fungal infections affect more than one million people globally, of which fungal
keratitis and endophthalmitis are the most common. These infections are the primary cause …