Therapeutic potential of intermittent hypoxia: a matter of dose

A Navarrete-Opazo, GS Mitchell - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial

HB Hayes, A Jayaraman, M Herrmann, GS Mitchell… - Neurology, 2014 - AAN Enterprises
Objectives: To test the hypothesis that daily acute intermittent hypoxia (dAIH) and dAIH
combined with overground walking improve walking speed and endurance in persons with …

[HTML][HTML] Time domains of the hypoxic ventilatory response and their molecular basis

ME Pamenter, FL Powell - Comprehensive Physiology, 2016 - ncbi.nlm.nih.gov
Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic
exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease …

Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function

EA Dale, F Ben Mabrouk, GS Mitchell - Physiology, 2014 - journals.physiology.org
Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …

[HTML][HTML] Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α

Y Cho, JE Shin, EE Ewan, YM Oh, W Pita-Thomas… - Neuron, 2015 - cell.com
Injured peripheral neurons successfully activate a proregenerative transcriptional program
to enable axon regeneration and functional recovery. How transcriptional regulators …

Intermittent hypoxia and neurorehabilitation

EJ Gonzalez-Rothi, KZ Lee, EA Dale… - Journal of applied …, 2015 - journals.physiology.org
In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

Hypoxia‐induced phrenic long‐term facilitation: emergent properties

MJ Devinney, AG Huxtable, NL Nichols… - Annals of the New …, 2013 - Wiley Online Library
As in other neural systems, plasticity is a hallmark of the neural system controlling breathing.
One spinal mechanism of respiratory plasticity is phrenic long‐term facilitation (pLTF) …

[HTML][HTML] Rapid and robust restoration of breathing long after spinal cord injury

PM Warren, SC Steiger, TE Dick… - Nature …, 2018 - nature.com
There exists an abundance of barriers that hinder functional recovery following spinal cord
injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 …

Transplantation of neural progenitors and V2a interneurons after spinal cord injury

LV Zholudeva, N Iyer, L Qiang, VM Spruance… - Journal of …, 2018 - liebertpub.com
There is growing interest in the use of neural precursor cells to treat spinal cord injury (SCI).
Despite extensive pre-clinical research, it remains unclear as to which donor neuron …