Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …

Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered
by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report …

Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …

Background Continual expression of PD-L1 in tumor cells is critical for tumor immune
escape and host T cell exhaustion, however, knowledge on its clinical benefits through …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …