Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …

RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all
aspects of RNA metabolism. These proteins bind or remodel RNA or RNA–protein …

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to
develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to …

Helicases and remodeling enzymes are ATP-dependent motor proteins that play a critical
role in every aspect of RNA and DNA metabolism. Most RNA-remodeling enzymes are …

Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of …

Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …

Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to
permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine …

To reveal the mechanism of processive strand separation by superfamily-2 (SF2) 3′→ 5′
helicases, we determined apo and DNA-bound crystal structures of archaeal Hel308, a …

Helicases are a ubiquitous class of enzymes involved in nearly all aspects of DNA and RNA
metabolism. Despite recent progress in understanding their mechanism of action, limited …