In silico clinical trials: concepts and early adoptions
Innovations in information and communication technology infuse all branches of science,
including life sciences. Nevertheless, healthcare is historically slow in adopting …
including life sciences. Nevertheless, healthcare is historically slow in adopting …
[HTML][HTML] Immunomodulatory peptides—A promising source for novel functional food production and drug discovery
M Pavlicevic, N Marmiroli, E Maestri - Peptides, 2022 - Elsevier
Immunomodulatory peptides are a complex class of bioactive peptides that encompasses
substances with different mechanisms of action. Immunomodulatory peptides could also be …
substances with different mechanisms of action. Immunomodulatory peptides could also be …
[HTML][HTML] In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products
Historically, the evidences of safety and efficacy that companies provide to regulatory
agencies as support to the request for marketing authorization of a new medical product …
agencies as support to the request for marketing authorization of a new medical product …
Hesperidin is a potential inhibitor against SARS-CoV-2 infection
FJ Cheng, TK Huynh, CS Yang, DW Hu, YC Shen… - Nutrients, 2021 - mdpi.com
Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses
great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of …
great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of …
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility
FT Musuamba, I Skottheim Rusten… - CPT …, 2021 - Wiley Online Library
The value of in silico methods in drug development and evaluation has been demonstrated
repeatedly and convincingly. While their benefits are now unanimously recognized …
repeatedly and convincingly. While their benefits are now unanimously recognized …
In silico design of recombinant multi-epitope vaccine against influenza A virus
Background Influenza A virus is one of the leading causes of annual mortality. The emerging
of novel escape variants of the influenza A virus is still a considerable challenge in the …
of novel escape variants of the influenza A virus is still a considerable challenge in the …
The combination of artificial intelligence and systems biology for intelligent vaccine design
Introduction A new body of evidence depicts the applications of artificial intelligence and
systems biology in vaccine design and development. The combination of both approaches …
systems biology in vaccine design and development. The combination of both approaches …
In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform
Background SARS-CoV-2 is a severe respiratory infection that infects humans. Its outburst
entitled it as a pandemic emergence. To get a grip on this outbreak, specific preventive and …
entitled it as a pandemic emergence. To get a grip on this outbreak, specific preventive and …
The COVID-19 vaccine development: a pandemic paradigm
DC Carneiro, JD Sousa, JP Monteiro-Cunha - Virus Research, 2021 - Elsevier
COVID-19 pandemic has resulted in millions of deaths and a social-economic crisis. A
worldwide effort was made to develop efficient vaccines for this disease. A vaccine should …
worldwide effort was made to develop efficient vaccines for this disease. A vaccine should …
In silico clinical trials for relapsing-remitting multiple sclerosis with MS TreatSim
Background The last few decades have seen the approval of many new treatment options
for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic …
for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic …