Abstract Objective Cancer-associated fibroblasts (CAFs) function as a crucial factor in tumor
progression by carrying exosomes to neighboring cells. This study was assigned to expound …

In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms:
cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) …

Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in
destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA …

Nonsense-mediated mRNA decay (NMD) is a highly regulated quality control mechanism
through which mRNAs harboring a premature termination codon are degraded. It is also a …

The stability and quality of metazoan mRNAs are under microRNA (miRNA)-mediated and
nonsense-mediated control. Although UPF1, a core mediator of nonsense-mediated mRNA …

Oncogenes can create metabolic vulnerabilities in cancer cells. We tested how AKT (herein
referring to AKT1) and MYC affect the ability of cells to shift between respiration and …

Nonsense‐mediated mRNA decay (NMD) degrades mRNAs carrying a premature
termination codon (PTC) in eukaryotes. Cellular stresses, including endoplasmic reticulum …

Heart development is a complex process regulated by multi-layered genetic as well
epigenetic regulators many of which are still unknown. Besides their critical role during …

La protéine AKT1, appelée aussi protéine kinase B ou PKB, est un composant central de la
voie de signalisation PI3K/AKT/mTOR qui représente une des voies majoritaires des …

Zusammenfassung Die Beteiligung des PI3K/Akt Signalwegs an zahlreichen zellulären
Prozessen wie der Proliferation, dem Überleben sowie der Proteinbiosynthese, macht ihn …