Background Malaria, caused by the parasitic protist Plasmodium falciparum, represents a
major public health problem in the developing world. The P. falciparum genome has been …

Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying
between transcription and protein synthesis, pre-mRNA splicing removes sequences …

The SWI/SNF (mating-type switch/sucrose nonfermenting) complex involved in chromatin
remodeling on promoters has also been detected on the coding region of genes. Here we …

SR proteins are a family of RNA binding proteins that contain a signature RS domain
enriched with serine/arginine repeats. The RS domain is also found in many other proteins …

The production of mRNAs in all living organisms is an extremely complex process that
includes multiple catalytic activities such as transcription, capping, splicing, polyadenylation …

During catalytic activation of the spliceosome, snRNP remodeling events occur, leading to
the formation of a 35S U5 snRNP that contains a large group of proteins, including Prp19 …

In the last several years, a number of studies have shown that spliceosome assembly and
splicing catalysis can occur co-transcriptionally. However, it has been unclear which specific …

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …

BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling
complexes mainly associated with transcriptional initiation. They also have a role in …

Alternative pre-mRNA splicing in higher eukaryotes enhances transcriptome complexity and
proteome diversity. Its regulation is mediated by a complex RNA-protein network that is …