Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR)
signals to make crucial cell-fate decisions at several checkpoints during their development …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

Gene expression profiling has revealed that diffuse large B cell lymphoma (DLBCL) consists
of at least two distinct diseases. Patients with one DLBCL subtype, termed activated B cell …

The cellular response to survive or to undergo death is fundamental to the benefit of the
organism, and errors in this process can lead to autoimmunity and cancer. The transcription …

Signal transduction events leading to the survival, differentiation, or apoptosis of cells of the
innate or adaptive immune system must be properly coordinated to ensure the normal …

The transcription factor NFκB is activated by numerous stimuli. Once NFκB is fully activated,
it participates in the regulation of various target genes in different cells to exert its biological …

SLP76 and SLP65 are adaptor proteins that lack intrinsic enzymatic activity but contain
multiple protein-binding domains. These proteins are essential for signalling downstream of …

In a search for genes specifically expressed in Reed–Sternberg (RS) cells of Hodgkin
lymphoma (HL), we applied the serial analysis of gene expression (SAGE) technique on the …

In a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation,
unmodulated, was isolated with profound defects in humoral immune responses, selective …

The p53 tumor suppressor protein is best known as an inhibitor of the cell cycle and an
inducer of apoptosis. Unexpectedly, these functions of p53 are not required for its tumor …