ROS signalling in the biology of cancer

JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Nox proteins in signal transduction

DI Brown, KK Griendling - Free Radical Biology and Medicine, 2009 - Elsevier
The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

P Niethammer, C Grabher, AT Look, TJ Mitchison - Nature, 2009 - nature.com
Barrier structures (for example, epithelia around tissues and plasma membranes around
cells) are required for internal homeostasis and protection from pathogens. Wound detection …

Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life

B Halliwell - Plant physiology, 2006 - academic.oup.com
The field of antioxidants and free radicals is often perceived as focusing around the use of
antioxidant supplements to prevent human disease. In fact, antioxidants/free radicals …

The Na+/I Symporter (NIS): Mechanism and Medical Impact

C Portulano, M Paroder-Belenitsky… - Endocrine …, 2014 - academic.oup.com
Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

Biomedical applications and potential health risks of nanomaterials: molecular mechanisms

S Lanone, J Boczkowski - Current molecular medicine, 2006 - ingentaconnect.com
Nanotechnologies, defined as techniques aimed to conceive, characterize and produce
material at the nanometer scale, represent a fully expanding domain, and one can predict …

The influence of reactive oxygen species on cell cycle progression in mammalian cells

EH Verbon, JA Post, J Boonstra - Gene, 2012 - Elsevier
Cell cycle regulation is performed by cyclins and cyclin dependent kinases (CDKs).
Recently, it has become clear that reactive oxygen species (ROS) influence the presence …

Hydrogen peroxide as a cell-survival signaling molecule

G Groeger, C Quiney, TG Cotter - Antioxidants & redox signaling, 2009 - liebertpub.com
Reactive oxygen species (ROS) were seen as destructive molecules, but recently, they have
been shown also to act as second messengers in varying intracellular signaling pathways …

Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases

TL Leto, S Morand, D Hurt, T Ueyama - Antioxidants & redox …, 2009 - liebertpub.com
Nox family NADPH oxidases serve a variety of functions requiring reactive oxygen species
(ROS) generation, including antimicrobial defense, biosynthetic processes, oxygen sensing …

Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions

SH Kim, WJ Lee - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
It is well-known that certain bacterial species can colonize the gut epithelium and induce
inflammation in the mucosa, whereas other species are either benign or beneficial to the …