Protein acylation: mechanisms, biological functions and therapeutic targets

S Shang, J Liu, F Hua - Signal Transduction and Targeted Therapy, 2022 - nature.com
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Fibroblast growth factor receptors as treatment targets in clinical oncology

M Katoh - Nature reviews Clinical oncology, 2019 - nature.com
FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

A not-so-ancient grease history: click chemistry and protein lipid modifications

KF Suazo, KY Park, MD Distefano - Chemical reviews, 2021 - ACS Publications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing

JA Whitley, H Cai - Journal of Extracellular Vesicles, 2023 - Wiley Online Library
Clustered regularly interspaced palindromic repeats (CRISPR) is a gene editing tool with
tremendous therapeutic potential. Recently, ribonucleoprotein (RNP) complex‐based …

Post-translational modifications that drive prostate cancer progression

I Samaržija - Biomolecules, 2021 - mdpi.com
While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

Long-chain acyl-CoA synthetase 4–mediated fatty acid metabolism sustains androgen receptor pathway–independent prostate cancer

Y Ma, X Zhang, OA Alsaidan, X Yang… - Molecular Cancer …, 2021 - AACR
Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway–
independent prostate cancer with dysregulated fatty acid metabolism. However, it is unclear …

Regulation of FGF10 signaling in development and disease

J Watson, C Francavilla - Frontiers in Genetics, 2018 - frontiersin.org
Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling
growth factor, which is essential for multi-organ development and tissue homeostasis in …

MiR-326: promising biomarker for cancer

YJ Pan, J Wan, CB Wang - Cancer Management and Research, 2019 - Taylor & Francis
MicroRNAs (miRNAs) are small non-coding and highly conserved RNAs that act in
biological processes including cell proliferation, invasion, apoptosis, metabolism, signal …

Fibroblast growth factor 10 alleviates acute lung injury by inhibiting excessive autophagy via Nrf2

S Huang, Y Xue, W Chen, M Xue, L Miao… - Journal of …, 2023 - joe.bioscientifica.com
Acute lung injury (ALI) is associated with an increased incidence of respiratory diseases,
which are devastating clinical disorders with high global mortality and morbidity. Evidence …

Comprehensive analysis of potential cellular communication networks in advanced osteosarcoma using single-cell RNA sequencing data

N Xu, X Wang, L Wang, Y Song, X Zheng… - Frontiers in Genetics, 2022 - frontiersin.org
Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis
and recurrence are the major causes of poor treatment outcomes. A better understanding of …