State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

Organisms are inherently three dimensional, thus comprehensive understanding of the
complicated biological system requires analysis of organs or even whole bodies in the …

Summary Three-dimensional (3D) optical imaging techniques can expand our knowledge
about physiological and pathological processes that cannot be fully understood with 2D …

Nicotine is a highly addictive compound present in tobacco, which causes the release of
dopamine in different regions of the brain. Recent studies have shown that astrocytes …

Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that
enlarges upon vasodilation, but its regulation is not completely understood. Here, we show …

Microglia are specialized resident macrophages of the central nervous system (CNS) that
have important functions during neurodevelopment, homeostasis and disease. This mini …

Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue
regeneration and functional recovery. However, the origin of scar-forming fibroblasts is …

Natural killer (NK) cell therapy is one of the most promising treatments for Glioblastoma
Multiforme (GBM). However, this emerging technology is limited by the availability of …

Neuromuscular junctions (NMJs) mediate skeletal muscle contractions and play an
important role in several neuromuscular disorders when their morphology and function are …