Hyaluronic acid

KL Goa, P Benfield - Drugs, 1994 - Springer
Hyaluronic acid is a naturally occurring Polysaccharide with distinct physicochemical
properties which underlie its application as a viscoelastic tool in ophthalmological surgery …

Pathogenesis of Graves' ophthalmopathy

RS Bahn, AE Heufelder - New England Journal of Medicine, 1993 - Mass Medical Soc
Ophthalmopathy is a potentially disfiguring and sight-threatening component of Graves'
disease. It is clinically evident in 25 to 50 percent of patients with Graves' hyperthyroidism …

Current perspectives on the role of orbital fibroblasts in the pathogenesis of Graves' ophthalmopathy

WA Dik, S Virakul, L van Steensel - Experimental Eye Research, 2016 - Elsevier
Graves' ophthalmopathy (GO) is an extra-thyroidal complication of Graves' disease (GD;
Graves' hyperthyroidism) characterized by orbital tissue inflammation, expansion …

Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I …

TJ Smith, N Hoa - The Journal of Clinical Endocrinology & …, 2004 - academic.oup.com
A distinctive histopathological feature associated with thyroid-associated ophthalmopathy is
the disordered accumulation of the glycosaminoglycan, hyaluronan, in orbital connective …

The pathophysiology of thyroid eye disease

SJC Shan, RS Douglas - Journal of Neuro-Ophthalmology, 2014 - journals.lww.com
The pathophysiology of thyroid eye disease (TED) is complex and incompletely understood.
Orbital fibroblasts (OFs) seem to be the key effector cells that are responsible for the …

Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy

TJ Smith, L Hegedüs, RS Douglas - Best practice & research Clinical …, 2012 - Elsevier
The etiology of Graves' orbitopathy (GO) remains enigmatic and thus controversy surrounds
its pathogenesis. The role of the thyroid stimulating hormone receptor (TSHR) and activating …

Detection of TSH receptor RNA in cultured fibroblasts from patients with Graves' ophthalmopathy and pretibial dermopathy

AE Heufelder, CM Dutton, G Sarkar, KA Donovan… - Thyroid, 1993 - liebertpub.com
Fibroblasts are target cells for the autoimmune process in Graves' ophthalmopathy and
pretibial dermopathy. Because the autoantigen involved in the hyperthyroidism of Graves' …

Insulinlike growth factor-I gene therapy applications for cartilage repair.

AJ Nixon, BD Brower-Toland, SJ Bent… - … Research (1976-2007 …, 2000 - journals.lww.com
Cartilage function after resurfacing with cell-based transplantation procedures or during the
early stages of arthritic disease may be bolstered by the addition of growth factor genes to …

Proliferative and matrix synthesis response of canine anterior cruciate ligament fibroblasts submitted to combined growth factors

EA DesRosiers, LH Yahia… - Journal of orthopaedic …, 1996 - Wiley Online Library
We investigated the effects of growth factors on the proliferation and matrix synthesis of
anterior cruciate ligament fibroblasts. Fibroblasts from the anterior cruciate ligaments of dogs …

Autoantibodies to the IGF1 receptor in Graves' orbitopathy

WB Minich, N Dehina, T Welsink… - The Journal of …, 2013 - academic.oup.com
Abstract Context: Graves' disease (GD) is maintained by stimulating antibodies against the
TSH receptor. Graves' orbitopathy (GO) is the main extrathyroidal manifestation of GD …