The autosomal dominant cerebellar ataxias (ADCAs) represent a heterogeneous group of
neurodegenerative diseases with progressive ataxia and cerebellar degeneration. The …

The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …

Summary Spinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat
neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and …

Spinocerebellar ataxias are dominantly inherited disorders that are associated with
progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of …

One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

Increasingly, repeat expansions are being identified as part of the complex genetic
architecture of amyotrophic lateral sclerosis. To date, several repeat expansions have been …

Background: Although several patient characteristic, clinical, and psychological risk factors
for chronic postsurgical pain (CPSP) have been identified, genetic variants including single …

Expansion of CAG trinucleotide repeats in ATXN1 causes spinocerebellar ataxia type 1
(SCA1), a neurodegenerative disease that impairs coordination and cognition. While ATXN1 …

PURPOSE OF REVIEW Neurodegenerative cerebellar ataxia is a diverse collection of
diseases that are unified by gait and balance abnormalities, appendicular incoordination …

Abstract Spinocerebellar ataxia type 1 (SCA1) is one of nine polyglutamine (polyQ) diseases
and is characterized as an adult late-onset, progressive, dominantly inherited genetic …