Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Background: Metastasis is a major cause of HCC-related deaths with no effective
pharmacotherapies. Chronic inflammation promotes HCC dissemination, however, its …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor
lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs …

Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …

Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been
found to play an essential role in the development of various human tissues, including …

Male infertility is a widespread health problem affecting approximately 6%–8% of the male
population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are …

Background In spite of great progress in the surgical and clinical management, until now no
significant improvement in overall survival of High-Grade Serous Ovarian Cancer (HGSOC) …

BHLHE40 is a transcription factor, whose role in colorectal cancer has remained elusive. We
demonstrate that the BHLHE40 gene is upregulated in colorectal tumors. Transcription of …