Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Magnetism plays a pivotal role in many biological systems. However, the intensity of the
magnetic forces exerted between magnetic bodies is usually low, which demands the …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Background High-grade serous ovarian carcinoma is characterised by TP53 mutations, DNA
repair defects, and genomic instability. We hypothesised that prexasertib (LY2606368), a …

To maintain genome stability, cells have evolved various DNA repair pathways to deal with
oxidative DNA damage. DNA damage response (DDR) pathways, including ATM-Chk2 and …

ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma …

Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment.
However, they have debilitating side effects in normal tissues and induce ototoxicity …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. 5-
Fluorouracil (5-FU) is widely used in the treatment of cancers, but its antineoplastic activity is …

The cell cycle involves a network of proteins that modulate the sequence and timing of
proliferation events. Unregulated proliferation is the most fundamental hallmark of cancer; …

There is a growing appreciation that the direct interaction between bacteriophages and the
mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these …