Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Pseudomonas aeruginosa is an opportunistic pathogen able to infect any human tissue.
One of the reasons for its high adaptability and colonization of host tissues is its capacity of …

The rise in nosocomial infections caused by multidrug-resistant pathogens is a major public
health concern. Patients taking immunosuppressants or chemotherapeutics are naturally …

Antimicrobial resistance is a major threat to global public health. Vaccination is an effective
approach for preventing bacterial infections, however it has not been successfully applied to …

Bordetella pertussis is the causative agent of whooping cough (pertussis), a severe
respiratory disease that can be fatal, particularly in infants. Despite high vaccine coverage …

Burkholderia pseudomallei is a gram-negative bacterium that is the etiological agent of the
tropical disease melioidosis. Currently, there is no licensed vaccine for melioidosis, but …

Multiple scarce nutrients, such as iron and nickel, are essential for bacterial growth. Gram-
negative bacteria secrete chelators to bind these nutrients from the environment …

Poorly immunogenic small molecules pose challenges for the production of clinically
efficacious vaccines and antibodies. To address this, we generate an immunization platform …

Mucosal surfaces are in contact with the external environment and protect the body from
infection by various microbes. To prevent infectious diseases at the first line of defense, the …

Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune
response seeded in the respiratory tract. An individual, once convalescent, exhibits long …