Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …

Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …

Adiponectin has emerged as a potential therapy for type 2 diabetes mellitus, but the
molecular mechanism by which adiponectin reverses insulin resistance remains unclear …

A metabolically flexible state exists when there is a rapid switch between glucose and fatty
acids during the transition between the fed and fasting state. This flexibility in fuel choice …

White adipose tissue (WAT) insulin action has critical anabolic function and is dysregulated
in overnutrition. However, the mechanism of short-term high-fat diet–induced (HFD-induced) …

Androgens have a complex role in the regulation of insulin sensitivity in the pathogenesis of
type 2 diabetes. In male subjects, a reduction in androgens increases the risk for insulin …

Several recent cardiovascular trials of SGLT 2 (sodium-glucose cotransporter 2) inhibitors
revealed that they could reduce adverse cardiovascular events in patients with T2DM (type 2 …

This study investigated the role of diacylglycerol (DAG)‐mediated protein kinase C (PKC)
activation, ceramide accumulation and inflammation in insulin‐resistant female oxidative …

It remains essential to decipher some of the pathological mechanisms that link obesity with
deteriorating human health. Insulin resistance, due to enhanced free fatty acid substrate …