Cooperative Conformational Transitions Underpin the Activation Heat Capacity in the Temperature Dependence of Enzyme Catalysis

EJ Walker, CJ Hamill, R Crean, MS Connolly… - ACS …, 2024 - ACS Publications
Many enzymes display non-Arrhenius behavior with curved Arrhenius plots in the absence
of denaturation. There has been significant debate about the origin of this behavior and …

Activation Heat Capacities in Pyridoxal Phosphate Enzymes

JP Erbez, GH Rangel, M Davila, JA Englade… - ACS …, 2024 - ACS Publications
Much attention has been given to the temperature dependence of enzyme catalyzed
reaction rates in the last∼ 100 years. Over the last couple of decades, it has become …