Reward signals in the cerebellum: origins, targets, and functional implications

D Kostadinov, M Häusser - Neuron, 2022 - cell.com
The cerebellum has long been proposed to play a role in cognitive function, although this
has remained controversial. This idea has received renewed support with the recent …

Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells

D Kostadinov, M Beau, M Blanco-Pozo… - Nature neuroscience, 2019 - nature.com
There is increasing evidence for a cerebellar contribution to cognitive processing, but the
specific input pathways conveying this information remain unclear. We probed the role of …

Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations

EA Fleming, GD Field, MR Tadross, C Hull - Nature Neuroscience, 2024 - nature.com
The cerebellar cortex has a key role in generating predictive sensorimotor associations. To
do so, the granule cell layer is thought to establish unique sensorimotor representations for …

Cognitive model discovery via disentangled RNNs

K Miller, M Eckstein, M Botvinick… - Advances in Neural …, 2024 - proceedings.neurips.cc
Computational cognitive models are a fundamental tool in behavioral neuroscience. They
embody in software precise hypotheses about the cognitive mechanisms underlying a …

Cerebellum, predictions and errors

LS Popa, TJ Ebner - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Making predictions and validating the predictions against actual sensory information is
thought to be one of the most fundamental functions of the nervous system. A growing body …

Representational geometry of perceptual decisions in the monkey parietal cortex

G Okazawa, CE Hatch, A Mancoo, CK Machens… - Cell, 2021 - cell.com
Lateral intraparietal (LIP) neurons represent formation of perceptual decisions involving eye
movements. In circuit models for these decisions, neural ensembles that encode actions …

[HTML][HTML] Brain-wide dynamics linking sensation to action during decision-making

A Khilkevich, M Lohse, R Low, I Orsolic, T Bozic… - Nature, 2024 - nature.com
Perceptual decisions rely on learned associations between sensory evidence and
appropriate actions, involving the filtering and integration of relevant inputs to prepare and …

Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum

W Heffley, C Hull - elife, 2019 - elifesciences.org
Classical models of cerebellar learning posit that climbing fibers operate according to a
supervised learning rule to instruct changes in motor output by signaling the occurrence of …

Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain

TJ Pisano, ZM Dhanerawala, M Kislin, D Bakshinskaya… - Cell reports, 2021 - cell.com
Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding
conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by …