ABSTRACT Introduction Molecular Dynamics (MD) simulations can support mechanism-
based drug design. Indeed, MD simulations by capturing biomolecule motions at finite …

The insulin-linked polymorphic region is a variable number of tandem repeats region of DNA
in the promoter of the insulin gene that regulates transcription of insulin. This region is …

Significant progress has recently been made in the application of oxidized graphene (GO)
quantum dots as enzyme mimics in various biomedical fields due to their bio‐compatibility …

DNA can self-assemble into G-quadruplexes and i-motifs non-canonical secondary
structures that are formed by guanine-rich sequences and the cytosine-rich sequences …

Folding thermodynamics, quantitatively described using parameters such as Δ G fold°, Δ H
fold°, and Δ S fold°, is essential for characterizing the stability and functionality of …

DNA sequences containing at least four runs of repetitive cytosines can fold into tetra‐helical
structures called i‐Motifs (iMs). The interest in these DNA secondary structures is increasing …

Intercalated binding of anthracycline anticancer drugs to DNA is associated with anticancer
mechanisms. The i-motif, a cytosine-rich DNA secondary structure found in the promoter …

DNA requires hydration to maintain its structural integrity. Crystallographic analyses have
enabled patterns of water arrangements to be visualized. We survey these water motifs in …

The insulin linked polymorphic region (ILPR) is a variable number of tandem repeats
(VNTR) region of DNA in the promoter of the insulin gene that regulates transcription of …