Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Abdominal aortic aneurysm: update on pathogenesis and medical treatments
J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
MicroRNAs in cardiovascular disease
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
Understanding the pathogenesis of abdominal aortic aneurysms
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
[HTML][HTML] Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling
Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The
microRNA-29 (miR-29) family has been found to prevent excess collagen expression in …
microRNA-29 (miR-29) family has been found to prevent excess collagen expression in …
Circulating microRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes
MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its
relevance to the long-term risk of developing metabolic disorders is unknown. We therefore …
relevance to the long-term risk of developing metabolic disorders is unknown. We therefore …
Elastin structure, synthesis, regulatory mechanism and relationship with cardiovascular diseases
K Wang, X Meng, Z Guo - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
As the primary component of elastic fibers, elastin plays an important role in maintaining the
elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and …
elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and …
MicroRNA-195 regulates metabolism in failing myocardium via alterations in sirtuin 3 expression and mitochondrial protein acetylation
Background: Heart failure leads to mitochondrial dysfunction and metabolic abnormalities of
the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The …
the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The …
Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis
MMP activation plays a causal role in the elastogenesis (production) and elastolysis
(degradation) in the arterial wall (Figure; Table). Elastin fibers are effectively digested by …
(degradation) in the arterial wall (Figure; Table). Elastin fibers are effectively digested by …