Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

GR Thomas, H Nadiminti… - International journal of …, 2005 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract
and can destroy the structure and function of organs involved in voice, speech, taste, smell …

[HTML][HTML] Prognostic relevance of cell proliferation in head and neck tumors

A Pich, L Chiusa, R Navone - Annals of oncology, 2004 - Elsevier
Cell proliferative activity has been extensively investigated in head and neck tumors.
Ki67/MIB-1 immunostaining, tritiated thymidine or bromodeoxyuridine labeling indices, DNA …

[图书][B] Pathology and genetics of head and neck tumours

L Barnes - 2005 - books.google.com
Pathology and Genetics of Head and Neck Tumoursis the latest volume in the new WHO
series, on histological and genetic typing of human tumours. This authoritative, concise …

[HTML][HTML] p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma

VL Brown, CA Harwood, T Crook, JG Cronin… - Journal of investigative …, 2004 - Elsevier
The p16 INK4a and p14 ARF tumor suppressor genes (TSGs) are encoded within the
CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the …

[HTML][HTML] The p16 (CDKN2a/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 …

L Ai, KK Stephenson, W Ling, C Zuo, P Mukunyadzi… - Modern pathology, 2003 - Elsevier
Abstract The p16 (CDKN2a/INK4a) gene is an important tumor-suppressor gene, involved in
the p16/cyclin-dependent kinase/retinoblastoma gene pathway of cell cycle control. The p16 …

Alterações genéticas em câncer de cabeça e pescoço

J Colombo, P Rahal - Revista Brasileira de Cancerologia, 2009 - rbc.inca.gov.br
O carcinoma de células escamosas de cabeça e pescoço (HNSCC) constitui o quinto tipo
de câncer mais comum mundialmente, com uma incidência anual global de 780.000 novos …

Frequent hypermethylation of DAPK, RARbeta, MGMT, RASSF1A and FHIT in laryngeal squamous cell carcinomas and adjacent normal mucosa

J Paluszczak, P Misiak, M Wierzbicka, A Woźniak… - Oral oncology, 2011 - Elsevier
Laryngeal cancers are the most frequent cancers of the head and neck region. While recent
observations indicate the occurrence of an epigenetic field defect in head and neck cancer …

DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: a review

Y Chen, C Chen - Head & Neck: Journal for the Sciences and …, 2008 - Wiley Online Library
Genetic aberrations, such as DNA copy number variation (CNV) and loss of heterozygosity
(LOH), have been implicated in head and neck squamous cell carcinoma (HNSCC) initiation …

Prognostic implications of loss of heterozygosity at 8p21 and 9p21 in head and neck squamous cell carcinoma

SW Coon, AT Savera, RJ Zarbo… - … journal of cancer, 2004 - Wiley Online Library
Loss of heterozygosity (LOH) in chromosomal regions that harbor tumor suppressor genes
from tumor tissue may lead to decreased survival time in cancer patients with squamous cell …

Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC)

DJ Smiraglia, LT Smith, JC Lang, LJ Rush… - Journal of medical …, 2003 - jmg.bmj.com
Head and neck squamous cell carcinomas (HNSCC) often metastasise to the cervical lymph
nodes. It is known for HNSCC as well as other cancers that progression from normal tissue …