The application of micro total analysis systems has grown exponentially over the past few
years, particularly diversifying in disciplines related to bioassays. The primary focus of this …

The theory of branching processes is an area of mathematics that describes situations in
which an entity exists for a time and then may be replaced by one, two, or more entities of a …

Since the advent of microfabrication technology and soft lithography, the lab-on-a-chip
concept has emerged as a state-of-the-art miniaturized tool for conducting the multiple …

As access to high-throughput sequencing technology has increased, the bottleneck in
biomedical research has shifted from data generation to data analysis. Here, we describe a …

A novel approach is introduced using nanoplasmonic microarray–based solid-phase
recombinase polymerase amplification (RPA) that offers high sensitivity and multiplexing …

Problems in engineering, computational science, and the physical and biological sciences
are using increasingly sophisticated mathematical techniques. Thus, the bridge between the …

Conventional solid phase amplification regimens such as solid phase PCR (SP–PCR),
asymmetric SP–PCR, and bridge PCR are mechanistically limited with respect to …

Solid-phase oligonucleotide amplification is of interest because of possible applications to
next-generation sequencing, multiplexed microarray-based detection, and cell-free synthetic …

Solid phase amplification (SPA), a new method to amplify DNA, is characterized by the use
of surface-bound primers. This limits the amplification to two-dimensional surfaces and …

Abstract Solid-phase PCR (SP-PCR) has attracted considerable interest in different research
fields since it allows parallel DNA amplification on the surface of a solid substrate. However …